Symbol
Name
ID

Ifngr1
interferon gamma receptor 1
MGI:107655

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgG level

Increased circulating IgM level

Leukocytosis

Histiocytosis

Enlarged mesenteric lymph node

Lymphadenopathy

Generalized lymphadenopathy

Splenomegaly

Hepatosplenomegaly

Increased inflammatory response

Osteomyelitis

Salmonella osteomyelitis

Pneumonia

Rheumatoid factor positive

Immunodeficiency

Asthma

Recurrent mycobacterial infections

Recurrent mycobacterium avium complex infections

Disease(s) Associated with IFNGR1

asthma

immunodeficiency 27A

immunodeficiency 27B

Mouse Phenotypes

immune system phenotype

arteritis

aortitis

abnormal osteoclast differentiation

increased splenocyte proliferation

abnormal uterine NK cell morphology

increased uterine NK cell number

abnormal lymphopoiesis

increased B cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased lymphocyte cell number

decreased macrophage cell number

spleen hypoplasia

abnormal immunoglobulin level

decreased IgG2a level

decreased IgG3 level

abnormal uterine NK cell physiology

abnormal cytotoxic T cell physiology

abnormal circulating chemokine level

decreased circulating interferon-gamma level

increased circulating interferon-gamma level

increased circulating interleukin-1 beta level

decreased circulating interleukin-12 level

increased circulating interleukin-6 level

decreased circulating tumor necrosis factor level

abnormal chemokine level

decreased interferon-gamma secretion

increased interferon-gamma secretion

decreased interleukin-12b secretion

increased interleukin-6 secretion

decreased tumor necrosis factor secretion

increased tumor necrosis factor secretion

decreased susceptibility to experimental autoimmune myasthenia gravis

increased susceptibility to experimental autoimmune encephalomyelitis

increased susceptibility to experimental autoimmune uveoretinitis

increased susceptibility to induced arthritis

decreased susceptibility to endotoxin shock

abnormal response to infection

decreased susceptibility to bacterial infection

increased susceptibility to bacterial infection

increased susceptibility to bacterial infection induced morbidity/mortality

increased susceptibility to Herpesvirales infection induced morbidity/mortality

increased susceptibility to Riboviria infection induced morbidity/mortality

increased susceptibility to parasitic infection

increased susceptibility to Herpesvirales infection

increased susceptibility to Poxviridae infection

increased susceptibility to Riboviria infection

increased susceptibility to graft versus host disease

Availability

Mouse Genotype

Ifngr1^m1Btlr/Ifngr1^m1Btlr

Ifngr1^tm1.1Rost/Ifngr1^tm1.1Rost

Ifngr1^tm1.2Rds/Ifngr1^tm1.2Rds

Ifngr1^tm1Agt/Ifngr1^tm1Agt

Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds
Tg(Itgax-cre,-EGFP)4097Ach/0 (conditional)

Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds
Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ (conditional)

Ifngr1^tm1Dmer/Ifngr1^tm1Dmer (conditional)

Ifngr1^tm1Dmer/Ifngr1^tm1Dmer
Tg(Thy1-cre)1Vln/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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